Methyl chloroglyoxylate → Methyl (n-(5-chloro-2-propionylphenyl)-N-phenylcarbamoyl)formate

HRID 1261780

反応式

HRID 1261780 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:3]=1.Cl[C:20](=[O:25])[C:21]([O:23][CH3:24])=[O:22]>C1(C)C=CC=CC=1>[CH3:24][O:23][C:21](=[O:22])[C:20]([N:12]([C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[C:8](=[O:11])[CH2:9][CH3:10])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:25]

参加物

4

反応物 2

HCID 79846Methyl chloroglyoxylateHCID 708166141-(4-Chloro-2-phenylamino-phenyl)-propan-1-one

生成物 1

HCID 70816656Methyl (n-(5-chloro-2-propionylphenyl)-N-phenylcarbamoyl)formate収率 87.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
110 °C

実験手順

A solution of 1-(4-chloro-2-phenylamino-phenyl)-propan-1-one (13.0 g, 50.2 mmol) in toluene (150 mL) at 25° C. was treated with methyl chlorooxoacetate (42.86 g, 350 mmol). The reaction mixture was then heated at 110° C. for 16 h. At this time, the reaction mixture was concentrated in vacuo to afford N-(5-chloro-2-propionyl-phenyl)-N-phenyl-oxalamic acid methyl ester (15.2 g, 87.6%). The material was used without further purification.

後処理

  1. concentrationAt this time, the reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-a297d1dbe3644a168057496ae77a228f
出典データセット
uspto-grants-2013_06
特許番号
US08471027B2

関連ノート

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