Hydrochloric Acid → 2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

HRID 1261955ノート

反応式

HRID 1261955 の反応式
[N+](C1C=C(N2CCNCC2)C=CC=1)([O-])=O.[CH3:16][C:17]([OH:35])([CH3:34])[CH2:18][N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([N+:31]([O-:33])=[O:32])[CH:26]=2)[CH2:21][CH2:20]1.Cl.O1C(C)(C)C1.C(Cl)Cl.CO>CO>[CH3:34][C:17]([OH:35])([CH3:16])[CH2:18][N:19]1[CH2:20][CH2:21][N:22]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([N+:31]([O-:33])=[O:32])[CH:26]=2)[CH2:23][CH2:24]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 11208Isobutylene oxideHCID 21226129Dichloromethane methanolHCID 866616672-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol 1-(3-Nitro-phenyl)-piperazine

生成物 1

HCID 632395022-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol 1-(3-Nitro-phenyl)-piperazine; hydrochloride (2.0 g, 0.0082 mol) was dissolved in Methanol (42.5 mL) and the reaction mixture was placed in a sealed tube. 1,2-epoxy-2-methylpropane (0.888 g, 0.0123 mol) was then added at room temperature and the reaction was allowed to stir overnight. The mixture was then reduced en vacuo and the product was isolated by Isco flash column chromatography (DCM/MeOH) to afford 1.60 grams of 2-Methyl-1-[4-(3-nitro-phenyl)-piperazin-1-yl]-propan-2-ol as a yellow powder.

後処理

  1. customthe reaction mixture was placed in a sealed tube

出典と根拠

ORDレコード
ord-1bdcca8675574905a11299be83036eb7
出典データセット
uspto-grants-2013_06
特許番号
US08471005B2

反応ノート

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