1-Methyl-1H-benzimidazol-6-amine → [7-(4-Methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl]-(3-methyl-3H-benzimidazol-5-yl)-amine

関与物質

反応手順

Following the synthetic and purification procedures described in Example 1293d, 2-methanesulfinyl-7-(4-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (75 mg, 0.22 mmol) was coupled with 3-methyl-3H-benzimidazol-5-ylamine (57 mg, 0.38 mmol) at 105° C. for 86 h to afford the title compound. Yield of TFA salt: 12 mg (10%) of brown powder. LC/MS: 419 (M+H); HPLC: 95% pure, RT=2.21 min; mp: lyophilyte; 1H NMR: (DMSO, δ) 10.11 (s, 1H), 9.33 (s, 1H), 9.14 (s, 1H), 8.43 (d, J=8.6, 2H), 8.40 (s, 1H), 8.11 (d, J=8.6, 2H), 7.81 (d, J=9.0, 1H), 7.70 (d, J=9.0, 1H), 7.34 (d, J=4.9, 1H), 7.08 (d, J=4.9, 1H), 3.85 (s, 3H), 3.30 (s, 3H).

情報源と証拠