5-Amino-2-(trifluoromethyl)benzimidazole → HCID 66712247、化合物

HRID 1262365

反応式

HRID 1262365 の反応式
CS([C:4]1[N:9]=[CH:8][C:7]2=[CH:10][CH:11]=[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)[N:6]2[N:5]=1)=O.[F:23][C:24]([F:36])([F:35])[C:25]1[NH:26][C:27]2[CH:33]=[C:32]([NH2:34])[CH:31]=[CH:30][C:28]=2[N:29]=1>>[CH3:22][S:19]([C:16]1[CH:17]=[CH:18][C:13]([C:12]2[N:6]3[C:7]([CH:8]=[N:9][C:4]([NH:34][C:32]4[CH:31]=[CH:30][C:28]5[N:29]=[C:25]([C:24]([F:36])([F:35])[F:23])[NH:26][C:27]=5[CH:33]=4)=[N:5]3)=[CH:10][CH:11]=2)=[CH:14][CH:15]=1)(=[O:21])=[O:20]

参加物

3

反応物 2

HCID 193455-Amino-2-(trifluoromethyl)benzimidazoleHCID 66711046HCID 66711046、化合物

生成物 1

HCID 66712247HCID 66712247、化合物

実験手順

Following the synthetic and purification procedures described in Example 1293d, 2-methanesulfinyl-7-(4-methanesulfonyl-phenyl)-pyrrolo[2,1-f][1,2,4]triazine (75 mg, 0.22 mmol) was coupled with 2-trifluoromethyl-3H-benzimidazol-5-ylamine (78 mg, 0.38 mmol) at 105° C. for 86 h to afford the title compound. Yield of TFA salt: 34 mg (26%) of brown powder; LC/MS: 473 (M+H); HPLC: 95% pure, RT=2.99 min; 1H NMR: (DMSO, δ) 9.73 (s, 1H), 9.09 (s, 1H), 8.51 (d, J=8.4, 2H), 8.40 (s, 1H), 8.13 (br s, 1H), 8.04 (d, J=8.4, 2H), 7.71 (m, 2H), 7.38 (d, J=4.9, 1H), 7.03 (d, J=4.9, 1H), 3.28 (s, 3H).

後処理

  1. custompurification procedures

出典と根拠

ORDレコード
ord-060a73472b9a4b1b83a832165498cc86
出典データセット
uspto-grants-2013_06
特許番号
US08471005B2

関連ノート

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