Ethyl butyrimidate → HCID 178512693、化合物

HRID 1262655ノート

反応式

HRID 1262655 の反応式
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10](NN)=[O:11])[N:9]=1)[C:2]([NH2:4])=[NH:3].C(=N)([O:18]CC)CCC.Cl.C(OC(=N)CCC)C>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]([OH:11])=[O:18])[N:9]=1)[C:2]([NH2:4])=[NH:3]

参加物

5

反応物 3

HCID 16634Ethyl butyrimidateHCID 12235055Ethyl butyrimidate hydrochlorideHCID 178512692HCID 178512692、化合物

生成物 1

HCID 178512693HCID 178512693、化合物収率 78%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.90 g (14.48 mol) of 2-guanidino-4-thiazole carboxylic acid hydrazide in 50 ml dry ethanol was slurried with 29.1 mmol of ethyl butyrimidate (prepared from 4.41 g (29.1 mmol) of ethylbutyrimidate hydrochloride) for 5 days at 25°. The slurry was filtered and washed with ethanol and ether and dried to give 3.071 g (78%) of 2-guanidino-4-thiazole carboxylic acid 2-butyriminohydrazide.

後処理

  1. filtrationThe slurry was filtered
  2. washwashed with ethanol and ether
  3. customdried

出典と根拠

ORDレコード
ord-988400eaa24e4ff1b359039abffa1ce3
出典データセット
uspto-grants-1984_06
特許番号
US04452987

反応ノート

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