Hydrochloric Acid → 2-Amino-6-trifluoromethylbenzyl chloride
反応式
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH2:4]O.[ClH:14]>>[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH2:4][Cl:14]参加物
3
実験手順
To 4.06 g (7.8 mmole) of 2-amino-6-trifluoromethylbenzyl alcohol in a pressure bottle was added 60 ml of concentrated hydrochloric acid, the bottled stoppered and immersed in an oil bath maintained at 100°. The mixture was stirred for 1.5 hr., cooled and the precipitate filtered under suction. The colorless solid was washed with water and dried under high vacuum, yielding 3.28 g (75% yield) of a colorless solid; mp 155°-161°. The sample was used as such without further purification.
後処理
- customimmersed in an oil bath
- temperaturemaintained at 100°
- temperature, cooled
- filtrationthe precipitate filtered under suction
- washThe colorless solid was washed with water
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-60e0efe7ac2948af85ab7841257830d6
- 出典データセット
- uspto-grants-1984_06
- 特許番号
- USRE031617
反応ノート
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