Hydrochloric Acid → Piperazine, 1-(3-fluoro-2-pyridinyl)-, hydrochloride (1:2)

HRID 1263220ノート

反応式

HRID 1263220 の反応式
[F:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][N:11](C(OCC)=O)[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[ClH:19]>>[ClH:19].[ClH:19].[F:1][C:2]1[C:3]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 20455069Ethyl 4-(3-fluoro-2-pyridinyl)-1-piperazinecarboxylate

生成物 1

HCID 20455072Piperazine, 1-(3-fluoro-2-pyridinyl)-, hydrochloride (1:2)

実験手順

A solution of 1-(3-fluoro-2-pyridinyl)-4-carbethoxy piperazine (700 mg, 2.76 mmol) in 50 ml of 6N hydrochloric acid is stirred at reflux under N2 for 6 hours and then concentrated under reduced pressure. The residue is recrystallized from an ethanol-ethyl acetate mixture to give 1-(3-fluoro-2-pyridinyl) piperazine dihydrochloride.

後処理

  1. temperatureat reflux under N2 for 6 hours
  2. concentrationconcentrated under reduced pressure
  3. customThe residue is recrystallized from an ethanol-ethyl acetate mixture

出典と根拠

ORDレコード
ord-cce929f7673d4e6e98b5a386c1bcf1ec
出典データセット
uspto-grants-1984_06
特許番号
US04456604

反応ノート

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