化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → 3-(2-Amino-ethyl)-5-bromo-1H-indole-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl-5-bromo-tryptamine-2-carboxylate hydrochloride | HCID 13241174 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-(2-Amino-ethyl)-5-bromo-1H-indole-2-carboxylic acid | HCID 762789 | 91% |
反応手順
1.00 g. (2.87 mmoles) of ethyl-5-bromo-tryptamine-2-carboxylate hydrochloride are boiled for 2 hours in a mixture of 10 ml. of ethanol and 10 ml. of 4 n aqueous sodium hydroxide solution. The mixture is cooled with ice, acidified to pH 6 with glacial acetic acid, and the separated crystals are collected by filtration. 0.75 g. (91%) of 5-bromo-tryptamine-2-carboxylic acid are obtained; m.p.: 248°-249° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04456607 |
| 出典データセット | uspto-grants-1984_06 |
| ORD ID | ord-13e442916f0e46d4a4244f6fb020ee22 |
| 出典メモ | uspto-grants-1984_06 |