Potassium Bromide → 7-Bromo-6-hydroxy-1-heptanol

HRID 1263274ノート

反応式

HRID 1263274 の反応式
[O:1]1[CH2:9][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].[Br-:10].[K+].C(=O)(O)[O-].[Na+]>C(O)(=O)C.O1CCCC1.CCOCC>[Br:10][CH2:9][CH:2]([OH:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8]

参加物

6

反応物 3

HCID 253877Potassium BromideHCID 516892Sodium BicarbonateHCID 136166735-(Oxiran-2-yl)pentan-1-ol

生成物 1

HCID 133660747-Bromo-6-hydroxy-1-heptanol

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 23444217Acetic acid tetrahydrofuran溶媒

実験手順

A mixture of 5 (120 mg, 0.9 mmol) in acetic acid-tetrahydrofuran (2 mL-0.4 mL) was treated with 0.3 mL of saturated aqueous potassium bromide solution at room temperature over 67 hours. It was then diluted with ether and poured into saturated aqueous sodium bicarbonate. The separated organic layer was washed with saturated sodium thiosulfite, saturated sodium chloride, and dried over magnesium sulfate. Evaporation of the solvent gave 127 mg of 7-bromo-6-hydroxy-1-heptanol (4).

後処理

  1. washThe separated organic layer was washed with saturated sodium thiosulfite, saturated sodium chloride
  2. dry with materialdried over magnesium sulfate
  3. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-e55ae0ea8bc44e1187f5e1d9052070fc
出典データセット
uspto-grants-1984_06
特許番号
US04456613

反応ノート

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