Formic Acid → Methyl 3-Formamidyl-2-methyl-4-methylsulfanylbenzoate

HRID 1263402ノート

反応式

HRID 1263402 の反応式
[NH2:1][C:2]1[C:3]([CH3:14])=[C:4]([CH:9]=[CH:10][C:11]=1[S:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6].[CH:15](O)=[O:16]>C(OC(=O)C)(=O)C>[CH:15]([NH:1][C:2]1[C:3]([CH3:14])=[C:4]([CH:9]=[CH:10][C:11]=1[S:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6])=[O:16]

参加物

4

反応物 2

HCID 284Formic AcidHCID 18616042Methyl 3-amino-2-methyl-4-methylsulfanylbenzoate

生成物 1

HCID 86758893Methyl 3-Formamidyl-2-methyl-4-methylsulfanylbenzoate

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

At 40° C., 4.75 g of methyl 3-amino-2-methyl-4-methylsulfanylbenzoate (0.05 mol) were added a little at a time to a mixture of 30 ml of acetic anhydride and 2.2 g of formic acid (0.05 mol). After 5 h, the solution was allowed to cool and poured into ice-water, and the mixture was extracted exhaustively with methylene chloride. The organic phases were washed and dried, and the solvent was subsequently removed. Yield: 4.7 g (0.044 mol).

後処理

  1. temperatureto cool
  2. extractionthe mixture was extracted exhaustively with methylene chloride
  3. washThe organic phases were washed
  4. customdried
  5. customthe solvent was subsequently removed

出典と根拠

ORDレコード
ord-7c259bcd7d5f46efb7af8313d7eae164
出典データセット
uspto-grants-2003_04
特許番号
US06541423B1

反応ノート

読み込み中…