Phosphoric Acid → 4-methylbenzothiazole-5-carboxylic Acid

HRID 1263404ノート

反応式

HRID 1263404 の反応式
[CH3:1][C:2]1[C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=[CH:4][C:3]=1[C:11]([O:13]C)=[O:12].P(=O)(O)(O)O>[OH-].[K+]>[CH3:1][C:2]1[C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=[CH:4][C:3]=1[C:11]([OH:13])=[O:12]

参加物

4

反応物 2

HCID 1004Phosphoric AcidHCID 18616057Methyl 4-Methylbenzothiazole-5-carboxylate

生成物 1

HCID 114809704-methylbenzothiazole-5-carboxylic Acid

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

実験手順

16.6 g of methyl 4-methylbenzothiazole-5-carboxylate (0.08 mol) were dissolved in 280 ml of 5% strength aqueous potassium hydroxide solution and heated at reflux for 2.5 h. After cooling, the mixture was acidified using phosphoric acid. The product was filtered off and subsequently dried.

後処理

  1. temperatureheated
  2. temperatureat reflux for 2.5 h
  3. temperatureAfter cooling
  4. filtrationThe product was filtered off
  5. customsubsequently dried

出典と根拠

ORDレコード
ord-9661301a5c1d4a79a1f6f2a60ed9e312
出典データセット
uspto-grants-2003_04
特許番号
US06541423B1

反応ノート

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