5-Bromo-2-methoxybenzene-1-sulfonyl chloride → 5-Bromo-2-methoxy-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide

反応式

[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Br:9][C:10]1[CH:11]=[CH:12][C:13]([O:20][CH3:21])=[C:14]([S:16](Cl)(=[O:18])=[O:17])[CH:15]=1>>[Br:9][C:10]1[CH:11]=[CH:12][C:13]([O:20][CH3:21])=[C:14]([S:16]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:17])=[O:18])[CH:15]=1

参加物

反応物 2

HCID 5200205-Bromo-2-methoxybenzene-1-sulfonyl chloride

HCID 104875194-Bromo-3-methylisoxazol-5-amine

生成物 1

HCID 186173335-Bromo-2-methoxy-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide収率 61%

実験手順

5-Bromo-2-methoxy-N-(4-bromo-3-methyl-5-isoxazolyl) benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 5-bromo-2-methoxybenzenesulfonyl chloride according to the procedures described in Example 30. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 192-195° C., yield 61%.

後処理

customThe crude product was purified by recrystallization from ethyl acetate/hexanes
customto give a crystalline solid, m.p. 192-195° C., yield 61%

出典と根拠

ORDレコード: ord-dd2f21ceddc748b7a3ebe838ce49d196
出典データセット: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06541498B2

反応ノート

読み込み中…

参加物