化工社化工社 化学情報印刷レポート · 研究参考用
Ethylene Glycol → Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Ethyl 4-oxocyclohexanecarboxylate | HCID 317638 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate | HCID 10488810 | — |
反応手順
4-oxo-cyclohexanecarboxylic acid ethyl ester (52.8 g, 0.31 mole, Merck, Order No. 814249), ethylene glycol (67.4 g, 1.08 mole) and p-toluenesulfonic acid (0.7 g) in toluene (160 ml) were stirred for 20 hours at RT, and the reaction solution was poured into diethyl ether (300 ml) and washed with water, sodium hydrogen carbonate solution and sodium chloride solution. The solution was dried (Na2SO4), concentrated by evaporation in vacuo, and the remaining colorless liquid was processed further without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728028B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-cf51c88887784dd4a140c68d1eeaed7a |
| 出典メモ | uspto-grants-2010_06 |