Hydrochloric Acid → 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride
反応式
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:19]>>[ClH:19].[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([OH:15])=[O:14])=[CH:17][CH:18]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1参加物
3
実験手順
Methyl 4-[2-(1-pyrrolidinyl)ethoxy]benzoate (5.3 g, 21.2 mol) in 1 N aqueous HCl (50 mL) was heated at reflux for 18 h. The reaction mixture was washed with ethyl acetate (2×20 mL). The aqueous solvent was removed under reduced pressure to give the desired acid as a white solid (5.55 g, 96%) after drying under vacuum at ambient temperature.
後処理
- temperatureat reflux for 18 h
- washThe reaction mixture was washed with ethyl acetate (2×20 mL)
- customThe aqueous solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-56d3a7cb790545a484f2d3a938bf450b
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06541499B1
反応ノート
読み込み中…