5-(Dimethylamino)pentanenitrile → 5-(Dimethylamino)amylamine

HRID 1264297ノート

反応式

HRID 1264297 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][N:8]([CH3:15])[CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[N:14]>CCOCC>[CH3:7][N:8]([CH3:15])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14]

参加物

4

反応物 2

HCID 53056495-(Dimethylamino)pentanenitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 34659255-(Dimethylamino)amylamine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

To a cooled (0° C.) solution of lithium aluminum hydride (8 ml, 0.5M in ether) is added, slowly, a solution of 5-(dimethylamino)-pentanenitrile (126 mg, 1 mmol, reference example 94a) in ether (1 mL). On complete addition, the cold bath is removed and stirring continued for 2 h. The reaction mixture is then cooled to 0° C. and quenched by dropwise addition of water (160 mL), sodium hydroxide solution (160 mL, 5M), then a further portion of water (160 mL). The resulting mixture is filtered through celite and the filtrate concentrated under reduced pressure to give an oil which is used without further purification.

後処理

  1. additionis added
  2. additionOn complete addition
  3. customthe cold bath is removed
  4. customquenched by dropwise addition of water (160 mL), sodium hydroxide solution (160 mL, 5M)
  5. filtrationThe resulting mixture is filtered through celite
  6. concentrationthe filtrate concentrated under reduced pressure
  7. customto give an oil which
  8. customis used without further purification

出典と根拠

ORDレコード
ord-2fc9aaaf4972498191a4e8b350251896
出典データセット
uspto-grants-2003_04
特許番号
US06541505B1

反応ノート

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