Phenethylamine → Tert-butyl 2-[(2-phenylethyl)amino]acetate
反応式
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>C1(C)C=CC=CC=1>[C:15]([O:14][C:12](=[O:13])[CH2:11][NH:9][CH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)([CH3:18])([CH3:17])[CH3:16]参加物
4
反応条件
- 温度
- 95 °C
実験手順
A solution of 12.6 ml (100 mmol) phenethylamine in 50 ml toluene was treated at RT with 7.4 ml (200 mmol) tert-butyl bromoacetate and heated at 95° C. for 4 h. After cooling (0° C.), filtration and evaporation of the filtrate, the residue was suspended in pentane, cooled (0° C.), filtrated and evaporated to give 11.5 g (98%) of phenethylamino-acetic acid tert-butyl ester as an oil, MS: 236 (MH+).
後処理
- temperatureAfter cooling
- filtration(0° C.), filtration and evaporation of the filtrate
- temperaturecooled (0° C.)
- filtrationfiltrated
- customevaporated
出典と根拠
- ORDレコード
- ord-6d65350112044a5fbc1818be7066ed20
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06541638B2
反応ノート
読み込み中…