反応式
[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10]OS(C)(=O)=O.CC(C)([O-])C.[K+]>CCOCC>[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]=[CH2:10]参加物
4
反応条件
- 温度
- -35 °C
実験手順
Dissolve methanesulfonic acid 2-(2-chloromethyl-phenyl)-ethyl ester (8.8 g, 35.4 mmol) in ether (80 mL) and cool to −35° C. Add potassium t-butoxide (10 g, 89 mmol) and stir for 30 minutes. Add water (50 mL) and ether (150 mL), extract, dry (Na2SO4) and purify by silica gel chromatography (2:3 methylene chloride/pentane) to give 1-chloromethyl-2-vinyl-benzene as a colorless oil (4.43 g, 82%).
後処理
- extractionAdd water (50 mL) and ether (150 mL), extract
- dry with materialdry (Na2SO4)
- custompurify by silica gel chromatography (2:3 methylene chloride/pentane)
出典と根拠
- ORDレコード
- ord-18cf2be087e047fbbc8e0f34bf08e9e2
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06544980B2
関連ノート
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