Hydrochloric Acid → 2-(1,1-Dimethylethyl)-5-benzothiazoleacetic acid

HRID 1264626ノート

反応式

HRID 1264626 の反応式
[C:1]([C:5]1[S:6][C:7]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]#N)=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-:17].[K+].Cl.C[OH:21]>O>[C:1]([C:5]1[S:6][C:7]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]([OH:21])=[O:17])=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 53849835HCID 53849835、化合物

生成物 1

HCID 186136132-(1,1-Dimethylethyl)-5-benzothiazoleacetic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

The product from Step 5 (0.90 g, 0.004 mol) was dissolved in methanol (8 ml) and a solution of potassium hydroxide pellets (0.35 g, 0.006 mol) in water (2 ml) was added. The mixture was refluxed for 17 hours and was then cooled to room temperature. The mixture was acidified with concentrated hydrochloric acid to pH4 and the resultant solution was diluted with water and extracted with ethyl acetate. The organic extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and the filtrate was evaporated in vacuo to afford 2-tert-butyl-5-benzothiazolylacetic acid (0.5 g) as a viscous oil.

後処理

  1. temperatureThe mixture was refluxed for 17 hours
  2. extractionextracted with ethyl acetate
  3. extractionThe organic extract
  4. washwas washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. customthe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-0ea0485db6224d25ad3e300a17fbc6d8
出典データセット
uspto-grants-2003_04
特許番号
US06544989B2

反応ノート

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