Methanol → Methyl 5-chloro-2,3-dihydroxybenzoate

HRID 1264650ノート

反応式

HRID 1264650 の反応式
S(=O)(=O)(O)O.[Cl:6][C:7]1[CH:8]=[C:9]([OH:17])[C:10]([OH:16])=[C:11]([CH:15]=1)[C:12]([OH:14])=[O:13].[CH3:18]O>>[Cl:6][C:7]1[CH:8]=[C:9]([OH:17])[C:10]([OH:16])=[C:11]([CH:15]=1)[C:12]([O:14][CH3:18])=[O:13]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 123948825-Chloro-2,3-dihydroxybenzoic acid

生成物 1

HCID 18613685Methyl 5-chloro-2,3-dihydroxybenzoate

実験手順

A mixture of methanol (60 ml) and sulfuric acid (5.2 ml) was stirred at room temperature. 5-Chloro-2,3-dihydroxybenzoic acid (0.11 mol) was added. The reaction mixture was stirred and refluxed for 20 hours, and then poured out onto ice. The precipitate was filtered off, washed with water, and dried, yielding 18.48 g of methyl 5-chloro-2,3-dihydroxybenzoate (intermediate 9; mp: 102° C.).

後処理

  1. stirringThe reaction mixture was stirred
  2. temperaturerefluxed for 20 hours
  3. additionpoured out onto ice
  4. filtrationThe precipitate was filtered off
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-70915e134a844ed1b78dfc4e36e9fbde
出典データセット
uspto-grants-2003_04
特許番号
US06544997B1

反応ノート

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