Methylamine → HCID 18613731、化合物

HRID 1264911ノート

反応式

HRID 1264911 の反応式
Br[CH:2]([C:4]1[N:5]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[C:6](=[O:14])[C:7]2[CH:13]=[CH:12][CH:11]=[N:10][C:8]=2[N:9]=1)[CH3:3].[CH3:22][NH2:23]>C(O)C>[F:21][C:18]1[CH:19]=[CH:20][C:15]([N:5]2[C:6](=[O:14])[C:7]3[CH:13]=[CH:12][CH:11]=[N:10][C:8]=3[N:9]=[C:4]2[CH:2]([NH:23][CH3:22])[CH3:3])=[CH:16][CH:17]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 18613734HCID 18613734、化合物

生成物 1

HCID 18613731HCID 18613731、化合物収率 83%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

A suspension of the bromide (18) (80 mg, 0.23 mmol) and 8.03M solution of methylamine in ethanol (0.64 mL) was heated to 40° C. for 3 h, and stirred at ambient temperature overnight. The resulting suspension was concentrated to dryness under reduced pressure, and the resulting light brown solid was taken up in dichloromethane and filtered through a silica-gel plug to give the title amine (19) (57 mg, 83%) as a beige solid (The crude material was directly taken through the next step without further purification).

後処理

  1. concentrationThe resulting suspension was concentrated to dryness under reduced pressure
  2. filtrationfiltered through a silica-gel plug

出典と根拠

ORDレコード
ord-f5bf2ac5284b49c18cd88cf820f2fea4
出典データセット
uspto-grants-2003_04
特許番号
US06545005B1

反応ノート

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