4-Pyridinecarbothioamide → Ethyl 4-[2-(4-pyridyl)-4-thiazolyl)benzoate hydrobromide

反応式

[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[Br:10][CH2:11][C:12]([C:14]1[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=1)=O>>[BrH:10].[N:5]1[CH:6]=[CH:7][C:2]([C:1]2[S:8][CH:11]=[C:12]([C:14]3[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=3)[N:9]=2)=[CH:3][CH:4]=1

参加物

反応物 2

HCID 27237884-Pyridinecarbothioamide

HCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

生成物 1

HCID 18613814Ethyl 4-[2-(4-pyridyl)-4-thiazolyl)benzoate hydrobromide収率 67%

実験手順

In the same manner as in Example 28, thioisonicotinamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-[2-(4-pyridyl)-4-thiazolyl]benzoate hydrobromide. The product was recrystallized from ethanol. Yield: 67%. Pale yellow prisms. Melting point: 248 to 250° C.

出典と根拠

ORDレコード: ord-aef2ebc0a30f438997aa3e748820571e
出典データセット: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06545009B1

反応ノート

読み込み中…