化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromo-2',4'-difluoroacetophenone → Methyl 3-[4-(2,4-difluorophenyl)-2-thiazolyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-2',4'-difluoroacetophenone | HCID 2774185 | — |
| 反応物 | Methyl 3-carbamothioylbenzoate | HCID 23279244 | — |
| 生成物 | Methyl 3-[4-(2,4-difluorophenyl)-2-thiazolyl]benzoate | HCID 18613919 | 69% |
反応手順
In the same manner as in Example 28, methyl 3-thiocarbamoylbenzoate was reacted with 2,4-difluorophenacyl bromide to obtain methyl 3-[4-(2,4-difluorophenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 69%. Pale yellow prisms. Melting point: 121 to 122° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06545009B1 |
| 出典データセット | uspto-grants-2003_04 |
| ORD ID | ord-5f0b24e3af384b42a4675a7710f40ee5 |
| 出典メモ | uspto-grants-2003_04 |