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2-Bromo-1-(3,4-difluorophenyl)ethan-1-one → Methyl 3-[4-(3,4-difluorophenyl)-2-thiazolyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-1-(3,4-difluorophenyl)ethan-1-one | HCID 2737032 | — |
| 反応物 | Methyl 3-carbamothioylbenzoate | HCID 23279244 | — |
| 生成物 | Methyl 3-[4-(3,4-difluorophenyl)-2-thiazolyl]benzoate | HCID 18613923 | 70% |
反応手順
In the same manner as in Example 28, methyl 3-thiocarbamoylbenzoate was reacted with 3,4-difluorophenacyl bromide to obtain-methyl 3-[4-(3,4-difluorophenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 70%. Colorless prisms. Melting point: 147 to 148° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06545009B1 |
| 出典データセット | uspto-grants-2003_04 |
| ORD ID | ord-af57159da4904095a7696de820981d73 |
| 出典メモ | uspto-grants-2003_04 |