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2-Acetylcyclopentanone → 2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-3-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Acetylcyclopentanone | HCID 98471 | — |
| 反応物 | [2,6-Dichloro-4-(trifluoromethyl)phenyl]hydrazine | HCID 688223 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-3-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole | HCID 18614743 | 75% |
反応手順
2-Acetyl cyclopentanone (0.12 mL, 1 mmol) and 2,6-dichloro-4-trifluoromethylphenylhydrazine (245 mg, 1 mmol) in EtOH (10 mL) was heated under reflux for 12 hr. EtOH was removed under reduced pressure and the product purified by flash chromatography on silica (10% EtOAc:Hexane): yield 75%. 1H NMR (CDCl3) δ 7.8 (s, 2H), 2.6 (m, 6H each), 2.2 (s, 3H); MS (M+) 335.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06545033B1 |
| 出典データセット | uspto-grants-2003_04 |
| ORD ID | ord-b8cd216525884c928aee59fbdc6f31bf |
| 出典メモ | uspto-grants-2003_04 |