Tributylphosphine → Tributylphosphanium chloride

HRID 1265215ノート

反応式

HRID 1265215 の反応式
C=CC1C=CC=CC=1.C=CC1C=CC(C=C)=CC=1.C1C=CC(C[Cl:26])=CC=1.[CH2:27]([P:31]([CH2:36][CH2:37][CH2:38][CH3:39])[CH2:32][CH2:33][CH2:34][CH3:35])[CH2:28][CH2:29][CH3:30]>C(Cl)Cl>[Cl-:26].[CH2:36]([PH+:31]([CH2:27][CH2:28][CH2:29][CH3:30])[CH2:32][CH2:33][CH2:34][CH3:35])[CH2:37][CH2:38][CH3:39]

参加物

4

反応物 2

HCID 13831TributylphosphineHCID 16211592Merrifield's peptide resin

生成物 1

HCID 21584914Tributylphosphanium chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Merrifield's peptide resin (Aldrich, 1.1 meq/g of Cl), 50.1 g was stirred in 250 mL of CH2Cl2 with 132.3 g of tri-n-butylphosphine under argon for 1 week. The slurry was filtered and the beads washed with 1.5 L of CH2Cl2. The product was dried in the air and then under vacuum to produce 61.9 g of tributylphosphonium chloride substituted polymer.

後処理

  1. filtrationThe slurry was filtered
  2. washthe beads washed with 1.5 L of CH2Cl2
  3. customThe product was dried in the air

出典と根拠

ORDレコード
ord-2a7355b955e047119205471d407054e8
出典データセット
uspto-grants-2003_04
特許番号
US06545102B1

反応ノート

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