Ethyl 2-cyanopyridine-4-carboxylate → 3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester
反応式
C(O[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]#[N:12])[CH:6]=1)C.[C:14]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])(=[O:16])[CH3:15].[Li]>>[C:18]([O:17][C:14](=[O:16])[CH2:15][C:4]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]#[N:12])[CH:6]=1)=[O:13])([CH3:21])([CH3:20])[CH3:19]参加物
3
実験手順
The title compound was prepared from 2-cyano-isonicotinic acid ethyl ester [CAS-No. 58481-14-4] by treatment with lithium tert.-butyl acetate according to general procedure K (method b). Obtained as a light brown solid (7.70 g).
出典と根拠
- ORDレコード
- ord-c276f4f5402542279f8793e953caf328
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06544985B2
反応ノート
読み込み中…