化工社化工社 化学情報印刷レポート · 研究参考用
Chlorosuccinimide → HCID 69687567、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | Ethyl 3-ethynylbenzoate | HCID 15540684 | — |
| 反応物 | Methyl 3-(3-methoxymethyl-isoxazol-5-yl)-benzoate | HCID 18548718 | — |
| 反応物 | Methoxy-acetaldehyde oxime | HCID 73450284 | — |
| 反応物 | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | HCID 69687567 | HCID 69687567 | — |
反応手順
The title compound was prepared from methyl 3-(3-methoxymethyl-isoxazol-5-yl)-benzoate [prepared by reaction of ethyl 3-ethynylbenzoate [CAS-No. 178742-95-5] with a mixture of NCS, 2-methoxyacetaldoxime [CAS-No. 71494-93-4], Et3N and cat. amount of pyridine in CHCl3 at 50° C. according to Tetrahedron 1984, 40, 2985-2988] by treatment with lithium tert.-butyl acetate according to general procedure K (method b). Obtained as a light yellow liquid (1.548 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06544985B2 |
| 出典データセット | uspto-grants-2003_04 |
| ORD ID | ord-369ae7ed22f04edd8f0f1357deacb4c2 |
| 出典メモ | uspto-grants-2003_04 |