Formamide → Methyl 3-[5-methyl-oxazol-4-yl]-benzoate
反応式
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](=O)[CH:11](Br)[CH3:12])[CH:5]=1.[CH:16]([NH2:18])=[O:17]>>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:18]=[CH:16][O:17][C:11]=2[CH3:12])[CH:5]=1参加物
3
実験手順
rac-3-(2-Bromo-propionyl)-benzoic acid methyl ester (5.42 g) and formamide (3.6 ml) were heated together to 130° C. for 5 h. The mixture was partitioned between AcOEt and brine, the organic layer was dried and evaporated and the residual oil was chromatographed on silica gel using AcOEt/hexane (1:4) as eluent to give 3-(5-methyl-oxazol-4-yl)-benzoic acid methyl ester (2.52 g) as white solid.
後処理
- customThe mixture was partitioned between AcOEt and brine
- customthe organic layer was dried
- customevaporated
- customthe residual oil was chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-bd11d937a89b4538a3bbfa336493f4eb
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06544985B2
反応ノート
読み込み中…