3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester → {2-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-fluoro-5-pyrrolidin-1-yl-phenyl}-carbamic acid tert.-butyl ester

HRID 1265682ノート

反応式

HRID 1265682 の反応式
[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:11]([F:19])=[CH:10][C:9]=1[NH2:20])([CH3:4])([CH3:3])[CH3:2].C([O:26][C:27](=O)[CH2:28][C:29]([C:31]1[CH:36]=[CH:35][N:34]=[C:33]([C:37]#[N:38])[CH:32]=1)=[O:30])(C)(C)C>>[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:11]([F:19])=[CH:10][C:9]=1[NH:20][C:27](=[O:26])[CH2:28][C:29]([C:31]1[CH:36]=[CH:35][N:34]=[C:33]([C:37]#[N:38])[CH:32]=1)=[O:30])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 695928163-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl esterHCID 69688999(2-Amino-4-fluoro-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert.-butyl ester

生成物 1

HCID 86586839{2-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-fluoro-5-pyrrolidin-1-yl-phenyl}-carbamic acid tert.-butyl ester

実験手順

The title compound was prepared from (2-amino-4-fluoro-5-pyrrolidin-1-yl-phenyl)-carbamic acid tert.-butyl ester (Example J15) and 3-(2-cyano-pyridin-4-yl)-3-oxo-propionic acid tert.-butyl ester (Example K3) according to the general procedure M. Obtained as a yellow solid (196 mg).

出典と根拠

ORDレコード
ord-953f110bf4584adea83438a1489d261f
出典データセット
uspto-grants-2003_04
特許番号
US06544985B2

反応ノート

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