Sodium Chloride → Moxifloxacin

HRID 1265944ノート

反応式

HRID 1265944 の反応式
[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20].Cl.[Cl-].[Na+]>O>[CH3:1][O:2][C:3]1[C:8]([N:9]2[CH2:17][C@@H:16]3[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15]3)[CH2:10]2)=[C:7]([F:18])[CH:6]=[C:5]2[C:19]([C:21]([C:27]([OH:29])=[O:28])=[CH:22][N:23]([CH:24]3[CH2:26][CH2:25]3)[C:4]=12)=[O:20]

参加物

4

反応物 2

HCID 5234Sodium ChlorideHCID 101526Moxifloxacin Hydrochloride

生成物 1

HCID 152946Moxifloxacin

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
121 °C

実験手順

The water is initially charged in a reaction vessel made of glass, and moxifloxacin hydrochloride is dissolved therein with stirring. Sodium chloride is added to the solution of the active compound and dissolved therein. An Fe(III) chloride solution is added to the mixture. The mixture is filtered through a 0.2 μm sterile filter and in each case 250 ml are filled into an infusion bottle which is closed and heated in an autoclave at 121° C. for 20 min.

後処理

  1. dissolutionis dissolved
  2. dissolutiondissolved
  3. filtrationThe mixture is filtered through a 0.2 μm
  4. filtrationsterile filter and in each case 250 ml
  5. additionare filled into an infusion bottle which
  6. customis closed

出典と根拠

ORDレコード
ord-537fac695b5f47cd9788065522379c4b
出典データセット
uspto-grants-2003_04
特許番号
US06548079B1

反応ノート

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