Ethanol → Ethyl 2-[4-(cyclopropanecarbonyl)phenyl]-2-methylpropanoate
反応式
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13](N)=[O:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[CH2:18]([OH:20])[CH3:19]>>[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13]([O:20][CH2:18][CH3:19])=[O:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1参加物
3
実験手順
Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionamide (100 mg) in ethanol and bubble in hydrochloride gas for 5 minutes while stirring. Reflux for 10 hours, distill off the ethanol and extract into ethyl acetate. Evaporate the solvent in vacuo to give the title compound as an oil (50 mg).
後処理
- custombubble in hydrochloride gas for 5 minutes
- temperatureReflux for 10 hours
- distillationdistill off the ethanol
- extractionextract into ethyl acetate
- customEvaporate the solvent in vacuo
出典と根拠
- ORDレコード
- ord-bd014fe1e565479ebcf9bf688018d5f7
- 出典データセット
- uspto-grants-2003_04
- 特許番号
- US06548675B2
反応ノート
読み込み中…