1-(3,3-Diethoxy-propyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile → 2,4-Dioxo-1-(3-oxo-propyl)-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile
反応式
C([O:3][CH:4](OCC)[CH2:5][CH2:6][N:7]1[CH:12]=[C:11]([C:13]#[N:14])[C:10](=[O:15])[NH:9][C:8]1=[O:16])C>O1CCOCC1>[O:16]=[C:8]1[NH:9][C:10](=[O:15])[C:11]([C:13]#[N:14])=[CH:12][N:7]1[CH2:6][CH2:5][CH:4]=[O:3]参加物
3
反応条件
- 温度
- 60 °C
実験手順
1-(3,3-diethoxy-propyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile (Prep 34, 50 mg, 0.21 mmol) was dissolved in dioxane (5 mL) and 1N HClaq (500 μl) was added. The mixture was warmed at 60° C. for 15 minutes. The solvents were evaporated and the residue submitted to liophilization to give 53 mg of the title compound (quantitative yield).
後処理
- addition1N HClaq (500 μl) was added
- customThe solvents were evaporated
出典と根拠
- ORDレコード
- ord-ee4295b20e334f398cc183b168edb499
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07727988B2
反応ノート
読み込み中…