3-(3-Cyano-phenyl)-N-[5-(3-hydroxymethyl-pyrrol-1-yl)-2-nitro-phenyl]-3-oxo-propionamide → 3-[7-(3-Hydroxymethyl-pyrrol-1-yl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile
反応式
[C:1]([C:3]1[CH:4]=[C:5]([C:9](=O)[CH2:10][C:11]([NH:13][C:14]2[CH:19]=[C:18]([N:20]3[CH:24]=[CH:23][C:22]([CH2:25][OH:26])=[CH:21]3)[CH:17]=[CH:16][C:15]=2[N+:27]([O-])=O)=[O:12])[CH:6]=[CH:7][CH:8]=1)#[N:2]>C1COCC1.O.[Fe].CC(O)=O>[OH:26][CH2:25][C:22]1[CH:23]=[CH:24][N:20]([C:18]2[CH:17]=[CH:16][C:15]3[N:27]=[C:9]([C:5]4[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=4)[C:1]#[N:2])[CH2:10][C:11](=[O:12])[NH:13][C:14]=3[CH:19]=2)[CH:21]=1参加物
4
実験手順
The title compound was prepared from 3-(3-cyano-phenyl)-N-[5-(3-hydroxymethyl-pyrrol-1-yl)-2-nitro-phenyl]-3-oxo-propionamide (Example M11) by reductive cyclization with Fe/HOAc in THF/H2O at 60° C. according to the general procedure J (method d). Obtained as a brown solid (18 mg).