Ammonia → HCID 69780111、化合物
反応式
CO[C:3]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH2:17][C:18](=[O:32])[NH:19][C:20]4[CH:26]=[C:25]([N:27]5[CH:31]=[CH:30][CH:29]=[CH:28]5)[CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:11]=2)[O:8][CH:9]=1)=[O:4].[NH3:33]>CO>[O:32]=[C:18]1[CH2:17][C:16]([C:12]2[CH:11]=[C:10]([C:7]3[O:8][CH:9]=[C:5]([C:3]([NH2:33])=[O:4])[N:6]=3)[CH:15]=[CH:14][CH:13]=2)=[N:22][C:21]2[CH:23]=[CH:24][C:25]([N:27]3[CH:28]=[CH:29][CH:30]=[CH:31]3)=[CH:26][C:20]=2[NH:19]1参加物
4
反応条件
- 温度
- 20 °C
実験手順
A suspension of 2-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-oxazole-4-carboxylic acid methyl ester (Example 25) (44mg) in a 5N solution (3 mL) of NH3 in MeOH was stirred at 20° C. for 3 d. Insoluble material was filtered off and the solution was evaporated in vacuum. The residue was triturated with EtOAc to give the title compound (22 mg) as light-yellow solid.