Diethanolamine → HCID 69779842、化合物
反応式
CO[C:3]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH2:17][C:18](=[O:32])[NH:19][C:20]4[CH:26]=[C:25]([N:27]5[CH:31]=[CH:30][CH:29]=[CH:28]5)[CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:11]=2)[O:8][CH:9]=1)=[O:4].[OH:33][CH2:34][CH2:35][NH:36][CH2:37][CH2:38][OH:39]>>[OH:33][CH2:34][CH2:35][N:36]([CH2:37][CH2:38][OH:39])[C:3]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH2:17][C:18](=[O:32])[NH:19][C:20]4[CH:26]=[C:25]([N:27]5[CH:28]=[CH:29][CH:30]=[CH:31]5)[CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:11]=2)[O:8][CH:9]=1)=[O:4]参加物
3
実験手順
A solution of 2-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-oxazole-4-carboxylic acid methyl ester (Example 25)(88 mg) in 2-(2-hydroxy-ethylamino)-ethanol (2 mL) was stirred at 50° C. for 6 h. The mixture was partitioned between H2O and EtOAc. The organic layer was dried and evaporated in vacuum, and the residue was triturated with EtOAc to give the title compound (32 mg) as light-yellow solid.
後処理
- customThe mixture was partitioned between H2O and EtOAc
- customThe organic layer was dried
- customevaporated in vacuum
- customthe residue was triturated with EtOAc