Dimethylformamide → HCID 18544790、化合物

HRID 1266924

反応式

HRID 1266924 の反応式
[F:1][C:2]([F:14])([C:5]([F:13])([F:12])[C:6]([F:11])([F:10])[CH:7]([F:9])[F:8])[CH2:3][OH:4].CN(C=O)C.C(=O)([O-])[O-].[K+].[K+].[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29](F)[N:28]=1>O>[F:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([O:4][CH2:3][C:2]([F:14])([F:1])[C:5]([F:12])([F:13])[C:6]([F:10])([F:11])[CH:7]([F:8])[F:9])[N:28]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 96412,2,3,3,4,4,5,5-Octafluoro-1-pentanolHCID 11430Potassium CarbonateHCID 739342,6-Difluoropyridine

生成物 1

HCID 18544790HCID 18544790、化合物収率 88.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A reaction flask was loaded with 2,2,3,3,4,4,5,5-octafluoropentanol (16.1 g), DMF (42 ml), anhydrous potassium carbonate (9.6 g), followed by stirring at room temperature for one hour. To this mixture, 2,6-difluoropyridine (8.0 g) was dropwise added. The temperature was raised to 60° C., and the mixture was stirred for four hours. The heating was stopped, and water was added to the reaction mixture, followed by extraction with ethyl acetate. The extract was condensed by an evaporator to give 2-fluoro-6-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-pyridine (20 g).

後処理

  1. temperatureThe temperature was raised to 60° C.
  2. stirringthe mixture was stirred for four hours
  3. extractionfollowed by extraction with ethyl acetate
  4. customcondensed
  5. customby an evaporator

出典と根拠

ORDレコード
ord-330d9699c2c744848e0eb9f9573a1571
出典データセット
uspto-grants-2003_04
特許番号
US06551682B1

関連ノート

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