1,2-Naphthoquinone → HCID 135754684、化合物

HRID 1266929ノート

反応式

HRID 1266929 の反応式
[C:1]1(=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]1=O.[NH:13]([C:15]1[C:20]([C:21]([F:24])([F:23])[F:22])=[C:19]([O:25][CH3:26])[N:18]=[C:17]([CH3:27])[N:16]=1)[NH2:14]>C(O)(=O)C>[CH3:26][O:25][C:19]1[N:18]=[C:17]([CH3:27])[N:16]=[C:15]([N:13]=[N:14][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:1]=2[OH:12])[C:20]=1[C:21]([F:24])([F:23])[F:22]

参加物

4

反応物 2

HCID 106671,2-Naphthoquinone2 回HCID 18544800HCID 18544800、化合物

生成物 1

HCID 135754684HCID 135754684、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
110 °C

実験手順

Then, a flask was loaded with acetic acid (50 ml) and 1,2-naphthoquinone (2.9 g), and the temperature was raised up to 110° C. with stirring to dissolve 1,2-naphthoquinone. To this mixture, 4-hydrazino-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine (4 g) was added in 30 minutes. After stirring at 110° C. for 3 hours, the heating was stopped and left to cool. The reaction mixture was filtrated. The filtrated crystals were recrystallized with dioxane to give crystals, which were then filtrated and dried to give intended crystals (2.3 g).

後処理

  1. stirringAfter stirring at 110° C. for 3 hours
  2. waitleft
  3. temperatureto cool
  4. filtrationThe reaction mixture was filtrated
  5. customThe filtrated crystals were recrystallized with dioxane
  6. customto give crystals, which
  7. filtrationwere then filtrated
  8. customdried
  9. customto give

出典と根拠

ORDレコード
ord-f9b3d5abc5944628b853fa1d429791b3
出典データセット
uspto-grants-2003_04
特許番号
US06551682B1

反応ノート

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