Ethanol → 2-Amino-3-methoxypyridine

HRID 1266939ノート

反応式

HRID 1266939 の反応式
[CH3:1][O:2][C:3]1[C:4]([N+:9]([O-])=O)=[N:5][CH:6]=[CH:7][CH:8]=1.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[SH-].C(O)C>O.C1(C)C=CC=CC=1>[NH2:9][C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][N:5]=1

参加物

6

反応物 3

HCID 702EthanolHCID 5560633-Methoxy-2-nitropyridineHCID 16211516Sodium sulfide nonahydrate

生成物 1

HCID 99203842-Amino-3-methoxypyridine収率 70.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 1140Toluene溶媒

反応条件

温度
70 °C

実験手順

Then, a reaction flask was loaded with this 3-methoxy-2-nitropyridine (9.0 g), sodium sulfide enneahydrate (64 g), ethanol (93 ml) and water (46 ml) and they were mixed, followed by stirring at 70° C. for 2.5 hours. Then, the mixture was cooled to room temperature. To this, toluene and water were added, followed by stirring. The organic layer was collected and washed with a saline solution, and then dried with sodium sulfate. This was filtrated and the filtrate was condensed to give 2-amino-3-methoxypyridine (5.1 g).

後処理

  1. additionwere mixed
  2. temperatureThen, the mixture was cooled to room temperature
  3. stirringby stirring
  4. customThe organic layer was collected
  5. washwashed with a saline solution
  6. dry with materialdried with sodium sulfate
  7. filtrationThis was filtrated
  8. customcondensed

出典と根拠

ORDレコード
ord-5ffa6e064cb244a3a4d125a5a4d4c577
出典データセット
uspto-grants-2003_04
特許番号
US06551682B1

反応ノート

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