4-Methyloxybenzyl chloride → N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-4-[4-(trifluoromethyl)phenyl]butyl}piperazinyl)acetamide

HRID 1267027

反応式

HRID 1267027 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:31])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([OH:30])[CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25](OC)=[CH:24][CH:23]=2)[CH2:14][CH2:13]1.[F:32][C:33]([F:43])([F:42])C1C=CC(CCl)=CC=1.COC1C=CC(CCl)=CC=1>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:31])[CH2:11][N:12]1[CH2:13][CH2:14][N:15]([CH2:18][CH:19]([OH:30])[CH2:20][CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:33]([F:43])([F:42])[F:32])=[CH:26][CH:27]=2)[CH2:16][CH2:17]1

参加物

4

反応物 3

HCID 699934-Methyloxybenzyl chlorideHCID 123096p-Trifluoromethylbenzyl chlorideHCID 12052937N-(2,6-dimethylphenyl)-2-{4-[4-(4-methoxyphenyl)-2-hydroxybutyl]piperazinyl}acetamide

生成物 1

HCID 10276533N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-4-[4-(trifluoromethyl)phenyl]butyl}piperazinyl)acetamide

実験手順

Compound 21 was prepared in a manner similar to that of compound 16 substituting 4-trifluoromethylbenzyl chloride for 4-methoxybenzyl chloride. (M+1)=464.2

出典と根拠

ORDレコード
ord-eee3d3073cd4467aa6155cd9d0138417
出典データセット
uspto-grants-2003_04
特許番号
US06552023B2

関連ノート

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