Hydrochloric Acid → 2-Oxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile

HRID 1267154ノート

反応式

HRID 1267154 の反応式
C([O:3][C:4](=O)[CH2:5][N:6]([C:14]1[CH:19]=[C:18]([C:20]#[N:21])[CH:17]=[CH:16][C:15]=1[NH2:22])C(OC(C)(C)C)=O)C.Cl.CCOCC>CO.O1CCOCC1>[C:20]([C:18]1[CH:19]=[C:14]2[C:15](=[CH:16][CH:17]=1)[NH:22][C:4](=[O:3])[CH2:5][NH:6]2)#[N:21]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 69839618HCID 69839618、化合物

生成物 1

HCID 185457712-Oxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile収率 99%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

N-Boc-2-amino-5-cyanophenylglycin ethyl ester (2.6 g, 8.17 mmol) in MeOH (20 mL) was treated with 4M HCl in dioxane (20 mL) at rt for 16 hours. To the mixture was added Et2O until no more solid appeared. The solid was collected, washed with Et2O, and dried by air to give the product (1.4 g, 82%). 1H NMR (CD3COCD3) δ 7.02 (d, J=8.4 Hz, 1H), 7.00 (d, J=1.8 Hz, 1H), 6.95 (d, J=8.4 Hz, 1H), 3.89 (s, 2H).

後処理

  1. customThe solid was collected
  2. washwashed with Et2O
  3. customdried by air

出典と根拠

ORDレコード
ord-2ba1725105f24295a2b8f2e0e81d9bbd
出典データセット
uspto-grants-2003_04
特許番号
US06552042B2

反応ノート

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