Potassium Hydroxide → 3-(2,3,4-Trimethoxyphenyl)-2-propenoic acid

HRID 1267626

反応式

HRID 1267626 の反応式
[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[CH:13]=[CH:14][C:15]([O:17]CC)=[O:16].[OH-].[K+]>C(O)C>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[CH:13]=[CH:14][C:15]([OH:17])=[O:16]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 67200008Ethyl 3-(2,3,4-trimethoxyphenyl)prop-2-enoate

生成物 1

HCID 1184003-(2,3,4-Trimethoxyphenyl)-2-propenoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 3-(2,3,4-trimethoxyphenyl)propenoate (1.15 g) was dissolved in ethanol (20 mL), and to the solution 10% potassium hydroxide (1.21 g) was added, and the mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, water was added to the residue, and the mixture was adjusted to pH 2 with 2 M hydrochloric acid and extracted with ethyl acetate. The resultant organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure, water
  2. additionwas added to the residue
  3. extractionextracted with ethyl acetate
  4. dry with materialThe resultant organic layer was dried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ee355e4fcc944a8797892894afbb4c5a
出典データセット
uspto-grants-2003_04
特許番号
US06552188B2

関連ノート

読み込み中…