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2,6-Diphenylpyridine → (R)-N-[3-nitro-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Diphenylpyridine | HCID 72920 | — |
| 反応物 | (2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid | HCID 2760712 | — |
| 反応物 | 2-Chloro-3-nitroaniline | HCID 14220016 | — |
| 生成物 | (R)-N-[3-nitro-2-chlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide | HCID 58964771 | — |
反応手順
The title compound was prepared by the method of Example 6 using (R)-(+)-2-hydroxy-2-methyl-3,3,3-trifluoropropanoic acid (Method 3) and 2-chloro-3-nitroaniline (Tetrahedron, 1999, 56 (2), 165-173) except that 2,6-diphenylpyridine was used instead of 2,6-di-t-butylpyridine. NMR (CDCl3) 1.77 (s, 3H), 3.58 (s, 1H), 7.44 (t, 1H), 7.63 (d, 1H), 8.66 (d, 1H), 9.27 (s, 1H); m/z 311.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06552225B1 |
| 出典データセット | uspto-grants-2003_04 |
| ORD ID | ord-de58347e36eb4e578562f5ea0378103f |
| 出典メモ | uspto-grants-2003_04 |