Potassium Carbonate → 7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one

HRID 1267766ノート

反応式

HRID 1267766 の反応式
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21](Cl)=[O:22])=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:11][O:10][C:8]1[CH:9]=[C:2]2[C:3]([CH:4]=[C:20]([C:17]3[CH:18]=[CH:19][C:14]([O:13][CH3:12])=[CH:15][CH:16]=3)[C:21](=[O:22])[O:1]2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 696002-Hydroxy-4-MethoxybenzaldehydeHCID 27346884-Methoxyphenylacetyl chloride

生成物 1

HCID 6889737-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one収率 89.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A suspension of 2-hydroxy-4-methoxybenzaldehyde (6.10 g), 4-methoxyphenylacetylchloride (11.1 g) and potassium carbonate (20 g) in acetone (400 ml) was heated under reflux for 2 hours. The reaction mixture was evaporated to remove the solvent, followed by addition of water. The resulting precipitates were collected by filtration and dried under reduced pressure to give 7-methoxy-3-(4-methoxyphenyl)-chromen-2-one (10.1 g, Yield 89%).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customThe reaction mixture was evaporated
  4. customto remove the solvent
  5. additionfollowed by addition of water
  6. customThe resulting precipitates
  7. filtrationwere collected by filtration
  8. customdried under reduced pressure

出典と根拠

ORDレコード
ord-f689324d1e8e4013bebc513e8b197ca4
出典データセット
uspto-grants-2003_04
特許番号
US06552068B1

反応ノート

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