3-Benzoyl-1-(4-chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione → 1-(4-Chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione

HRID 12678

反応式

HRID 12678 の反応式
C([N:9]1[C:14](=[O:15])[C:13]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([CH3:22])[CH:17]=2)=[CH:12][N:11]([CH2:23][CH2:24][CH2:25][CH2:26][Cl:27])[C:10]1=[O:28])(=O)C1C=CC=CC=1>N.CO>[Cl:27][CH2:26][CH2:25][CH2:24][CH2:23][N:11]1[CH:12]=[C:13]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([CH3:22])[CH:17]=2)[C:14](=[O:15])[NH:9][C:10]1=[O:28]

参加物

4

反応物 1

HCID 589941843-Benzoyl-1-(4-chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione

生成物 1

HCID 589941791-(4-Chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione

試薬・触媒・溶媒 2

HCID 222Ammonia溶媒HCID 887Methanol溶媒

実験手順

3-Benzoyl-1-(4-chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione (Prep 45, 100 mg, 0.25 mmol) was dissolved in a solution of 3% NH3 in MeOH (5 mL). The mixture was stirred at room temperature for 3 hours, the solvent was then evaporated under vacuum to give the title compound that was used in the next step without further purification.

後処理

  1. customthe solvent was then evaporated under vacuum

出典と根拠

ORDレコード
ord-67e7e7cac166413a9063e2eaf416ec76
出典データセット
uspto-grants-2010_06
特許番号
US07727988B2

関連ノート

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