Diisobutylaluminum hydride → (E)-3-(2',3'-dichloro-biphenyl-4-yl)-but-2-en-1-ol

反応式

[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12](/[C:15](/[CH3:22])=[CH:16]/[C:17](OCC)=[O:18])=[CH:11][CH:10]=1.CC(C[AlH]CC(C)C)C>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12](/[C:15](/[CH3:22])=[CH:16]/[CH2:17][OH:18])=[CH:11][CH:10]=1

参加物

反応物 2

HCID 14487Diisobutylaluminum hydride

HCID 22557696(E)-Ethyl 3-(2',3'-dichloro-biphenyl-4-yl)-but-2-enoate

生成物 1

HCID 69801043(E)-3-(2',3'-dichloro-biphenyl-4-yl)-but-2-en-1-ol

実験手順

(E)-Ethyl 3-(2′,3′-dichloro-biphenyl-4-yl)-but-2-enoate (1.07 g, 3.19 mmol) was reduced with DIBAL-H by a procedure analogous to that described in example 52b to give (E)-3-(2′,3′-dichloro-biphenyl-4-yl)-but-2-en-1-ol as a colourless solid; 0.74 g (79%).

出典と根拠

ORDレコード: ord-0c72a5e9f3fc47ed907e487883bcabc9
出典データセット: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06555577B1

反応ノート

読み込み中…