(2,6-Dimethoxyphenyl)boronic acid → HCID 22557551、化合物

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1B(O)O.Br[C:15]1[CH:20]=[CH:19][C:18](/[C:21](/[CH3:28])=[CH:22]/[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:17][CH:16]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[C:15]1[CH:20]=[CH:19][C:18](/[C:21](/[CH3:28])=[CH:22]/[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:17][CH:16]=1

参加物

反応物 2

HCID 2734343(2,6-Dimethoxyphenyl)boronic acid

HCID 15933615(E)-ethyl 3-(4-bromophenyl)-but-2-enoate

生成物 1

HCID 22557551HCID 22557551、化合物収率 73%

実験手順

(E)-Ethyl 3-(2′,6′-dimethoxy-biphenyl-4-yl)-but-2-enoate (1.02 g, 73% yield) was prepared from 2,6-dimethoxyphenylboronic acid (1.20 g, 6.60 mmol) and (E)-ethyl 3-(4-bromophenyl)-but-2-enoate (1.0 g, 4.40 mmol) by a procedure analogous to that described in example 52a.

出典と根拠

ORDレコード: ord-4efe699f17954951abc9380d30fb98e4
出典データセット: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06555577B1

反応ノート

読み込み中…