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2,3-Dimethylaniline → 2-(2',3'-Dimethylphenylaminomethyl)-2-imidazoline hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-Dimethylaniline | HCID 6893 | — |
| 反応物 | 2-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride | HCID 2760928 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(2',3'-Dimethylphenylaminomethyl)-2-imidazoline hydrochloride | HCID 20481270 | 77% |
反応手順
31 g of 2-chloromethyl-2-imidazoline hydrochloride and 48.4 g of 2,3-dimethylaniline are refluxed for 5 hours in 65 ml of absolute ethanol. After cooling, the crystallised substance is collected by suction and recrystallised from water, affording 36 g (77% yield) of the final product with a melting point of 242° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04254133 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-e06acf45d0b04201b442b52954b92b8f |
| 出典メモ | uspto-grants-1981_03 |