Acetaldehyde → 1-(1-Chloroethyl)-4-(2-methylpropyl)benzene

HRID 1268413ノート

反応式

HRID 1268413 の反応式
[CH2:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[CH:11](=O)[CH3:12].[ClH:14]>[Cl-].[Zn+2].[Cl-]>[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([Cl:14])[CH3:12])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3]

参加物

5

反応物 3

HCID 177AcetaldehydeHCID 313Hydrochloric AcidHCID 10870Isobutylbenzene2 回

生成物 1

HCID 30173041-(1-Chloroethyl)-4-(2-methylpropyl)benzene

試薬・触媒・溶媒 1

HCID 3007855Zincchloride触媒

実験手順

Isobutylbenzene (402 g, 3 mol) and zinc chloride (136 g, 1 mol) are fed into a one liter flask equipped with termometer, stirrer, and gas inlet tube. The reaction is maintained below 10° C. by external cooling. A mixture of acetaldehyde (44 g, 1 mol) and isobutylbenzene (67 g, 0.5 mol) are added to the flask dropwise for 2 hours while maintaining the temperature of the flask below 10° C. The reaction is heated to room temperature and HCl is passed through the reaction medium in the flask for about 2 hours. The reaction is stirred for 6 hours. The solution is quenched with water and the organic layer is separated from the aqueous layer. The organic layer is washed with sodium bicarbonate and water, and then dried. It is then stripped of isobutylbenzene and vacuum distilled to give 1-(4′-isobutylphenyl)ethyl chloride.

後処理

  1. customequipped with termometer, stirrer, and gas inlet tube
  2. temperatureThe reaction is maintained below 10° C. by external cooling
  3. additionare added to the flask dropwise for 2 hours
  4. temperaturewhile maintaining the temperature of the flask below 10° C
  5. customThe solution is quenched with water
  6. customthe organic layer is separated from the aqueous layer
  7. washThe organic layer is washed with sodium bicarbonate and water
  8. customdried
  9. distillationdistilled

出典と根拠

ORDレコード
ord-0b18df2bd7c14edc82ce41840a621aa1
出典データセット
uspto-grants-2003_04
特許番号
US06555704B1

反応ノート

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