3-((4,5-Dichloro-2-nitrophenyl)amino)-1-propanol → 3-[(2-Amino-4,5-dichlorophenyl)amino]-1-propanol hydrochloride

HRID 126847

反応式

HRID 126847 の反応式
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][CH2:10][CH2:11][CH2:12][OH:13])=[C:4]([N+:14]([O-])=O)[CH:3]=1.[H][H]>[Ni].CO>[ClH:1].[NH2:14][C:4]1[CH:3]=[C:2]([Cl:1])[C:7]([Cl:8])=[CH:6][C:5]=1[NH:9][CH2:10][CH2:11][CH2:12][OH:13]

参加物

5

反応物 2

HCID 1129553-((4,5-Dichloro-2-nitrophenyl)amino)-1-propanolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 202880583-[(2-Amino-4,5-dichlorophenyl)amino]-1-propanol hydrochloride

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A mixture of 39.7 parts of 3-[(4,5-dichloro-2-nitrophenyl)amino]-1-propanol and 400 parts of methanol is hydrogenated at normal pressure and at room temperature with 5 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off. The filtrate is acidified with 24 parts of a hydrochloric acid solution while stirring. The solvent is evaporated and the solid residue is stirred in 2-propanol. The product is filtered off and dried in vacuo, yielding 31.5 parts of 3-[(2-amino-4,5-dichlorophenyl)amino]-1-propanol hydrochloride; mp.+185° C.

後処理

  1. filtrationthe catalyst is filtered off
  2. customThe solvent is evaporated
  3. stirringthe solid residue is stirred in 2-propanol
  4. filtrationThe product is filtered off
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-2f89da76172242f2aab915842e9330a7
出典データセット
uspto-grants-1981_03
特許番号
US04254127

関連ノート

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