ethyl N-(2-cyano-3-ethoxyacryloyl)carbamate → 1-(3,3-Diethoxy-butyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile

HRID 12685

反応式

HRID 12685 の反応式
C([O:3][C:4](=O)[NH:5][C:6](=[O:14])[C:7]([C:12]#[N:13])=[CH:8]OCC)C.[CH2:16]([O:18][C:19]([O:24][CH2:25][CH3:26])([CH3:23])[CH2:20][CH2:21][NH2:22])[CH3:17]>O>[CH2:25]([O:24][C:19]([O:18][CH2:16][CH3:17])([CH3:23])[CH2:20][CH2:21][N:22]1[CH:8]=[C:7]([C:12]#[N:13])[C:6](=[O:14])[NH:5][C:4]1=[O:3])[CH3:26]

参加物

4

反応物 2

HCID 230015ethyl N-(2-cyano-3-ethoxyacryloyl)carbamateHCID 86014913HCID 86014913、化合物

生成物 1

HCID 686958921-(3,3-Diethoxy-butyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

(2-Cyano-3-ethoxy-acryloyl)-carbamic acid ethyl ester (Prep32, 500 mg, 2.3 mmol) was suspended in water (20 mL) and 3,3-diethoxybutylamine (816 μl, 4.7) was added and the mixture warmed at 80° C. for 10 minutes. The reaction mixture was lyophilized and the residue was purified by flash chromatography with petroleum ether-ethyl acetate (1-1) to give 553 mg of the title compound as a white solid (83% yield).

後処理

  1. customthe residue was purified by flash chromatography with petroleum ether-ethyl acetate (1-1)

出典と根拠

ORDレコード
ord-316478c22577439eb2471c1a36ff2cc8
出典データセット
uspto-grants-2010_06
特許番号
US07727988B2

関連ノート

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